Fluoxetine - FDA prescribing information, side effects and
The safety and effectiveness in pediatric patients 8 years of age in Major Depressive Disorder and 7 years of age in OCD have not been established. However, because Fluoxetine crosses the placenta and because of the possibility that Fluoxetine may have adverse effects on the newborn, Fluoxetine should be used during labor and delivery only if the potential benefit justifies the potential risk to the fetus. How to take fluoxetine All possible dosages and drug forms may not be included here. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behavior. Hepatic Impairment In subjects with cirrhosis of the liver, the clearances of fluoxetine and its active metabolite, norfluoxetine, were decreased, thus increasing the elimination half-lives of these substances. Plasma fluoxetine and norfluoxetine concentration decrease gradually at the conclusion of therapy, which may minimize the risk of discontinuation symptoms with this drug. Accumulation and Slow Elimination The relatively slow elimination of fluoxetine (elimination half-life of 1 to 3 days after acute administration and 4 to 6 days after chronic administration) and its active metabolite, norfluoxetine (elimination half-life of 4 to 16 days. Fluoxetine and Olanzapine in Combination is indicated for the treatment of: Acute treatment of depressive episodes associated with Bipolar I Disorder in adult.
Fluoxetine Oral : Uses, Side Effects, Interactions
Long Elimination Half-Life Because of the long elimination half-lives of the parent drug and its major active metabolite, changes in dose will not be fully reflected in plasma for several weeks, affecting both strategies for titration to final dose and withdrawal from treatment. Panic Disorder clinical trials. Table 4 provides combined data for the pool of studies that are provided separately by indication in Table. Studies in animals also suggest that fluoxetine is a much more potent uptake inhibitor of serotonin than of norepinephrine. Feeling anxious or trouble sleeping Common possible side effects in people who take fluoxetine include: unusual dreams sexual problems loss of appetite, diarrhea, indigestion, nausea or vomiting, weakness, or dry mouth flu symptoms feeling tired or fatigued change in sleep. Patients should be advised of the following issues and asked to alert their healthcare provider if these occur while taking Fluoxetine tablets. Do not drink alcohol while using fluoxetine. Patients should be advised to consult with their healthcare provider if their symptoms do not improve with Fluoxetine. Fluoxetine Description Fluoxetine hydrochloride USP is a selective serotonin reuptake inhibitor for oral administration. Do not use Fluoxetine for a condition for which it was not prescribed. Hemic and Lymphatic System-Infrequent: ecchymosis; Rare: petechia, purpura.
Fluoxetine Capsules - FDA prescribing information, side
Fluoxetine was initiated at 10 mg/day for the first week, after which patients were dosed in a range of 20 mg/day to 60 mg/day on the basis of clinical response and tolerability. Subsequently, the physician may continue decreasing the dose but at a more gradual rate. Enantiomers Fluoxetine is a racemic mixture (50/50) of R-fluoxetine and S-fluoxetine enantiomers. See Clinical Studies (14.1). You should not drive, operate heavy machinery, or do other dangerous activities until you know how fluoxetine affects you. All patientsAs with other drugs effective in the treatment of MDD, the full effect may be delayed until 4 weeks of treatment or longer. For some patients it may be advisable to titrate up to this target dose over several days. These include specific antipsychotics (eg, ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol specific antibiotics (eg, erythromycin, gatifloxacin, moxifloxacin, sparfloxacin Class IA antiarrhythmic medications (eg, quinidine, procainamide Class III antiarrhythmics (eg, amiodarone, sotalol and others (eg, pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron. Because Fluoxetine is excreted in human milk, nursing while taking Fluoxetine is not recommended see Use in Specific Populations (8.3). No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some olderindividuals cannot be ruled out.