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Serum lithium and serum creatinine levels should be obtained several days after beginning metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. Vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures). In a study of 14 healthy, adult, female volunteers, administration of Flagyl 375 Capsules under fasting conditions produced a mean Cmax.9 (.5) mcg/mL, a mean Tmax.5 (.4) hours, and.

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Renal Impairment Decreased renal function does not alter the single-dose pharmacokinetics of metronidazole. Fertility was restored in most rats after an eight week, drug-free recovery period. Total and differential leukocyte counts should be made before and after re-treatment. Renal clearance of metronidazole is approximately 10 mL/min/1.73.

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There are published data from case-control studies, cohort studies, and 2-meta-analyses that include more than 5000 pregnant women who used metronidazole during pregnancy. Aseptic meningitis Cases of aseptic meningitis have been reported with metronidazole. In addition, patients have reported headache, syncope, dizziness, vertigo, incoordination, ataxia, confusion, dysarthria, irritability, depression, weakness, and insomnia (see warnings ). Fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species. In infants whose gestational ages were between 28 and 40 weeks, the corresponding elimination half-lives ranged from 109.5 hours. Metronidazole failed to produce any adverse effects on fertility or testicular function in male rats at doses up to 400 mg/kg/day (similar to the maximum recommended clinical dose based on body surface area comparisons) for 28 days. This effect is harmless and will disappear when the medication is stopped. Metronidazole has shown mutagenic activity in in vitro assay systems including the Ames test. Three studies conducted to assess the risk of infant cancer following metronidazole exposure during pregnancy did not show an increased risk; however, the ability of these studies to detect such a signal was limited.

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