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CH, lB Myanmar Htin Kyaw tip on Lnh o cao cp bidv. These thoughts may also be associated with your condition. Thus, the dose of TCAs may need to be reduced and plasma TCA concentrations may need to be monitored temporarily when fluoxetine is coadministered or has been recently discontinued see warnings AND precautions and clinical pharmacology. Prozac was also significantly more effective than placebo on the HAM-D subscores for depressed mood, sleep disturbance, and the anxiety subfactor. 1 and FD C YellowNo. Take fluoxetine exactly as prescribed by your doctor. Stay alert to changes in your mood or symptoms. The interaction between fluoxetine and other highly protein-bound drugs has not been fully evaluated, but may be important. You should not drive, operate heavy machinery, or do otherdangerous activities until you know how prozac affects you. Tell your doctor right away if you become pregnant. In US placebo-controlled clinical trials for OCD, insomnia was reported in 28 of patients treated with prozac and in 22 of patients treated with placebo. Tell your doctor about all your current medicines and any you start or stop using, especially: any other antidepressant;. Pediatric Pharmacokinetics (Children And Adolescents) Fluoxetine pharmacokinetics were evaluated in 21 pediatric patients (10 children ages 6 to 13, 11 adolescents ages 13 to 18) diagnosed with Major Depressive Disorder or Obsessive Compulsive Disorder ( OCD ). Prozac is primarily metabolized by CYP2D6. These differences can be almost entirely explained by differences in weight.