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Metronidazole can cause unusual results with certain medical tests. Further, some patients may tolerate one treatment regimen better than the other. Pediatric Patients In one study, newborn infants appeared to demonstrate diminished capacity to eliminate metronidazole. Warnings Precautions warnings Central And Peripheral Nervous System Effects Encephalopathy And Peripheral Neuropathy Cases of encephalopathy and peripheral neuropathy (including optic neuropathy) have been reported with metronidazole. Vaginalis infection is a venereal disease. Drug/Laboratory Test Interactions Metronidazole may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, sgot alanine aminotransferase (ALT, sgpt lactate dehydrogenase (LDH triglycerides, and glucose hexokinase. From Infectious Disease Resources Featured Centers Health Solutions From Our Sponsors. Bactericidal concentrations of metronidazole have also been detected in pus from hepatic abscesses. Medication Guide patient information Interaction With Alcohol Discontinue consumption of alcoholic beverages or products containing propylene glycol while taking flagyl and for at least three days afterward because abdominal cramps, nausea, vomiting, headaches, and flushing may occur (see contraindications and drug interactions ). Do not drink alcohol or consume foods or medicines that contain propylene glycol while you are taking metronidazole and for at least 3 days after you stop taking. Take the missed dose as soon as you remember. For Anaerobes Quantitative methods are used to determine antimicrobial inhibitory concentrations (MICs). See also: Flagyl and alcohol (in more detail) Avoid alcohol or propylene glycol for at least 3 days after you stop taking metronidazole.
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Lower respiratory tract infections, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the. Get medical help right away if you have any very serious side effects, including: unsteadiness, seizures, mental/mood changes (such as confusion trouble speaking, numbness/tingling of arms/legs, eye pain, sudden vision changes, headache that is severe or doesn't go away, stiff/painful neck. Plasma concentrations of metronidazole are proportional to the administered dose. Hematopoietic Reversible neutropenia ( leukopenia rarely, reversible thrombocytopenia. The dosage regimen should be individualized. Dizziness, headache, stomach upset, nausea, vomiting, loss of appetite, diarrhea, constipation, or metallic taste in your mouth may occur. In any event, the sexual partner should be treated with flagyl in cases of reinfection. Discontinue metronidazole if elevation of liver function tests occurs, and monitor liver function tests until the baseline values are reached. Subjects with end-stage renal disease ( esrd ; clcr.19.1 mL/min) and who received a single intravenous infusion of metronidazole 500 mg had no significant change in metronidazole pharmacokinetics but had 2-fold higher Cmax of hydroxy-metronidazole and 5-fold higher Cmax. If you use a breast pump during this time, throw out any milk you collect. A reduction in metronidazole dosage by 50 is recommended in patients with severe (Child-Pugh C) hepatic impairment (see dosage AND administration ).
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Hepatic Impairment Following a single intravenous infusion of 500 mg metronidazole, the mean AUC24 of metronidazole was higher by 114 in patients with severe (Child-Pugh C) hepatic impairment, and by 54 and 53 in patients with mild (Child-Pugh A) and moderate (Child-Pugh. Mammary and hepatic tumors were increased among female rats administered oral metronidazole compared to concurrent controls. Less than 20 of the circulating metronidazole is bound to plasma proteins. Thus, on account of the potential accumulation of metronidazole metabolites in esrd patients, monitoring for metronidazole associated adverse events is recommended (see precautions ). In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to flagyl. In animal studies, metronidazole caused certain types of cancers or tumors. No dosage adjustment is needed for patients with mild to moderate hepatic impairment. There are published data from case-control studies, cohort studies, and 2 meta-analyses that include more than 5000 pregnant women who used metronidazole during pregnancy. These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. Do not take this medicine in larger or smaller amounts or for longer than recommended. To reduce the development of drug-resistant bacteria and maintain the effectiveness of flagyl and other antibacterial drugs, flagyl should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 2 Lake, hydroxypropyl cellulose, hypromellose, polyethylene glycol, stearic acid, and titanium dioxide. Tell your doctor if you are pregnant or if you become pregnant while using this medicine.